Sirtuin-1 is required for proper trophoblast differentiation and placental development. Mus musculus

In this study we identified that Sirt1 is important for mouse trophoblast stem cell (TSC) differentiation. The transcriptome of wild-type and Sirt1-null TSC were analyzed to identify dysregulation of signaling pathways. Overall design: In order to identify gene expression changes in TSC in the absence of Sirt1, we performed genome-wide expression profiling of Wild-type and Sirt1-null TSCs derived from a littermate pair of embryos on the 129S1/SvlmJ genetic background.