Data from: Disrupted hippocampal theta-gamma coupling and spike-field coherence following experimental traumatic brain injury

Traumatic brain injury (TBI) often results in persistent learning and
memory deficits, likely due to disrupted hippocampal circuitry underlying
these processes. Precise temporal control of hippocampal neuronal activity
is thought to be important for memory encoding and retrieval and is
supported by oscillations that dynamically organize single unit firing.
Using high-density laminar electrophysiology, we found a loss of
oscillatory power across CA1 lamina, with a profound, layer-specific
reduction in theta-gamma phase amplitude coupling in injured rats.
Interneurons from injured animals were less strongly entrained to theta
and gamma oscillations, but both interneurons and pyramidal cells from
injured animals became more strongly entrained to theta during periods of
high theta power. During quiet immobility, sharp-wave ripple amplitudes
were lower in injured animals compared to shams. These results reveal
physiological deficits across brain states that may contribute to
TBI-associated learning and memory impairments and elucidate potential
targets for future neuromodulation therapies.