P-selectin binds P-selectin ligand

PSGL-1 is expressed as a homodimer of two 120-kDa subunits that binds all four selectins, with the highest affinity for P-selectin, and is known to be constitutively expressed on the surface of platelets and most types of leukocytes. Besides playing a critical role in the inflammatory response by mediating leukocyte-leukocyte and leukocyte-endothelium interactions, PSGL-1 also participates in the hemostatic process by mediating leukocyte-platelet interactions.

PSGL-1作为一种由两个120-kDa亚基组成的同源二聚体表达，能与四种选择素结合，对P选择素的亲和力最高，并在血小板表面以及大多数白细胞类型表面持续表达。PSGL-1不仅在通过调节白细胞-白细胞及白细胞-内皮细胞相互作用在炎症反应中发挥关键作用，亦通过调节白细胞-血小板相互作用参与止血过程。