Effect of NaHCO3 on mutant V. cholerae ability to colonize the infant mouse intestine in competition with the parental strain (wild type).

aThe competitive index is the ratio of mutant to parental (WT) cfu in the small intestine post infection divided by the input ratio of mutant to parental (WT) cfu. The average and SEM of 4–7 mouse experiments is shown for each mutant. The NaHCO3 treatments that causes significant rescue of the mutant colonization defect are indicated (* p3 treatment did not cause significant rescue of the ΔhmpA mutant (p>0.05).