Transcriptional and interactome network analyses of Substantia Nigra in progressive stages of Parkinson’s disease

We analyzed the transcriptomic profile of post-mortem substantia nigra explants from controls, intermediate - Braak 3 (BK3) and 4 (BK4) - stages of Parkinson’s disease in order to investigate how gene-gene interaction patterns vary along disease development. The comparative transcriptional networks analyses indicate that the main hubs in CT network showed less gene-gene connections in BK3 and BK4 networks, probably reflecting changes in SN cell metabolism, population and density along PD stages. Substantia nigra transcriptomic profiles of controls and intermediate stages of Parkinson’s disease were compared using ANOVA in order to identify differentially expressed transcripts