Combination effect, <i>in vitro</i>, between forms of Selenium and Chemotherapy drugs.

Legend ↑ Additive effect exists where the Combination Index = 1. In the article, where the authors calculated the CI and the CI was found to be equal to 1. + Positive impact – where the use of the two agents in series or combination resulted in increased growth inhibition that was greater than the single agent alone. /± No impact found. ↓ Negative impact where the use of the two agents in series or combination resulted in decreased growth inhibition versus the drug agent. CDDP Cisplatin. DOC Docetaxel. DOX Doxorubicin. MIC Mitomycin C. MSeA Methylselenic Acid. PAX Paclitaxel. S Sodium selenite. SN38 Active metabolite of irinotecan. VP-16 Etoposide. ySe Yeast derived selenium.