Transcriptome profiling of regulatory T cells from children with Transient Hypogammaglobulinemia of Infancy

In this study, we aimed to determine the role of Treg cells in the pathomechanism of THI, based on the gene expression profile analysis performed on isolated Treg cells. Study was performed in THI patients at two time points, during, and in resolution phase of hypogammaglobulinemia, we showed changes in the expression profile of genes important for Treg lymphocyte biology and function. In parallel, we analyzed expression profiles of long intergenic non-coding RNA as well as microRNA precursors. This study improved our understanding of the role of Treg-related genes in the etiopathogenesis of THI. Microarray expression analysis was performed for Treg cell population isolated from THI patients in two time-points: during (THI-1) and in resolution phase of hypogammaglobulinemia (THI-2).