Influence of evernic acid alone and in combination with temozolomide on gene expression of U-87 glioblastoma cell line

to investigate the sensitization mechanism of temozolomide-resistant U-87 cells by evernic acid, we established gene expression of U-87 cells treated with evernic acid, temozolomide and their combinations compared to the gene expression of untreated cells. The NGS-core facility of the University Hospital Bonn of Bonn University performed the RNA-sequencing. Overall design: cells were treated with evernic acid at 30 µM and 45 µM, with temozolomide at 600 µM, and with combinations of evernic acid and temozolomide at 35 µM + 320 µM, 20 µM + 380 µM and 20 µM + 580 µM