Integrated single-cell transcriptomic atlas of human tricuspid and aortic valve diseases

This dataset contains processed single-cell RNA sequencing (scRNA-seq) data from human tricuspid valve (TV) and aortic valve (AV) leaflets, including samples from tricuspid regurgitation (TR), calcific aortic valve disease (CAVD), and corresponding controls. The dataset includes expression matrices, cell type annotations, and metadata. Data were integrated and analyzed to characterize cellular composition, transcriptional programs, and intercellular interactions across valve types and disease conditions. Original datasets were obtained from publicly available sources (HRA010091 and PRJNA562645). This resource is intended to facilitate further investigation into valvular biology and disease-associated transcriptional changes.本数据集包含经过预处理的人类三尖瓣（tricuspid valve, TV）与主动脉瓣（aortic valve, AV）瓣叶的单细胞RNA测序（single-cell RNA sequencing, scRNA-seq）数据，样本涵盖三尖瓣反流（tricuspid regurgitation, TR）、钙化性主动脉瓣疾病（calcific aortic valve disease, CAVD）以及对应的健康对照样本。 该数据集包含表达矩阵、细胞类型注释文件与元数据。研究人员对数据进行了整合与分析，以解析不同瓣膜类型及疾病状态下的细胞组成、转录程序与细胞间互作模式。 原始数据集取自公开可用的资源（HRA010091与PRJNA562645）。本数据集旨在推动瓣膜生物学及疾病相关转录变化领域的后续研究。