rat gut metagenome Raw sequence reads. rat gut metagenome

The sometimes inappropriate use of prescription antibiotics during early life can alter colonization patterns influencing susceptibility to both infectious and chronic disease. Widely used as an antimicrobial in bar soaps, triclocarban (3,4,4′-trichlorocarbanilide; TCC) is effective against Gram positive bacteria, but shows little efficacy against Gram negative strains. Recently, a final ruling was issued by the FDA to remove these products from the market which should substantially reduce human exposure to TCC. To date, the consequence of continuous or previous antimicrobial exposure from compounds in personal care products on commensal microbiota is still elusive. In this report, we utilized a rodent model to investigate and characterize the temporal changes of the biodiversity and composition of intestinal microbiota of post-weaned rats in response to continuous oral TCC exposure and investigated the resilience of the gut microbiome when TCC exposure was removed.