Spatial and temporal intra-tumoural heterogeneity in advanced High-Grade Serous Ovarian Cancer: implications for surgical and clinical outcomes

Limited evidence exists on the extent and impact of spatial and temporal heterogeneity of high grade serous ovarian cancer (HGSOC) on tumour evolution and patients surgical and clinical outcome. We investigated this through systematic mapping of multi-site tumours at initial presentation and matched relapse from 49 chemo-naïve HGSOC patients with high tumour load, operated upfront.
Our data provides a unique insight into the tumour evolution and metastatic pathways of HGSOC across time and space, how this
complexity relates to surgical and clinical outcome and its consequences on clinical decision-making.EGA study EGAS00001007164