An intron SNP rs2069837 in IL-6 is associated with osteonecrosis of the femoral head development

Two variants (rs2069837, and rs13306435) in the IL-6 gene were identified and genotyped from 566 patients with ONFH and 566 healthy controls. The associations between IL-6 polymorphisms and ONFH susceptibility were assessed using odds ratio (OR) and 95% confidence interval (95% CI) via logistic regression. The results of the overall analysis revealed that IL-6 rs2069837 is correlated with decreased risk of ONFH among the Chinese Han population (<em>p</em> &lt; 0.05). In stratified analysis, rs2069837 also reduced the susceptibility to ONFH in older people (&gt; 51 years), males, nonsmokers, and nondrinkers (<em>p</em> &lt; 0.05).本研究从566例股骨头坏死（Osteonecrosis of the Femoral Head, ONFH）患者与566名健康对照者中，鉴定并完成了白细胞介素6（Interleukin-6, IL-6）基因的两个变异位点（rs2069837与rs13306435）的基因分型。本研究采用比值比（odds ratio, OR）与95%置信区间（95% confidence interval, 95% CI），通过logistic回归分析，评估IL-6基因多态性与ONFH易感性之间的关联。整体分析结果显示，在中国汉族人群中，IL-6基因rs2069837位点与股骨头坏死发病风险降低呈显著相关（P<0.05）。分层分析进一步表明，在年龄＞51岁人群、男性、非吸烟者及非饮酒者亚组中，rs2069837位点同样可降低股骨头坏死的发病易感性（P<0.05）。