Spatial transcriptomics reveals altered communities and drivers of aberrant epithelia and pro-fibrotic fibroblasts in interstitial lung diseases

Interstitial lung diseases (ILD) are characterized by fibrotic scarring of the distal lung parenchyma with remarkably unfavorable prognosis. Here we generated a comprehensive portrait of diverse cell types in distal lung and investigated how their spatial organization is altered in fibrosis. We provide the cloupe files for each individual Visium run which can be visualized using the Loupe browser. Each file also contains additional metadata on community membership and annotated histopathological feature for each visium spot overlaid on top of the H&E stained image.间质性肺疾病（Interstitial lung diseases, ILD）以远端肺实质的纤维化瘢痕为典型特征，预后极差。本研究刻画了远端肺组织中多种细胞类型的完整图谱，并探究了纤维化状态下这些细胞的空间排布如何发生改变。 我们提供了每一轮Visium实验的cloupe文件，可通过Loupe浏览器进行可视化。每个文件还包含额外的元数据，涵盖每个Visium斑点的群落归属信息，以及叠加于苏木精-伊红（H&E）染色图像之上的注释组织病理学特征。