Bromodomain and Extraterminal Inhibition Blocks Inflammation-Induced Cardiac Dysfunction and SARS-CoV2 Infection

Bulk RNA-sequencing of lungs and hearts from a SARS-CoV2 infection study. K18-hACE2 mice (strain B6.Cg-Tg(K18-ACE2)2Prlmn/J) were infected with SARS-CoV2 (10 mice) and there were 5 non-infected controls. Infected mice were given 67 mg/kg INCB054329 or a vehicle control [30% (m/v) Kolliphor 15 HS (Sigma) in PBS] at 1, 2 and 3 days post infection. Mice were euthanized and organs harvested at 4 d.p.i. Libraries were prepared from ribosomal depleted total RNA and sequenced on a NextSeq 500/550 v2 (Illumina) with 150 bp reads.