NTRK2 activates RAS signaling through SHC1

SHC1-mediated recruitment of GRB2:SOS1 to the activated NTRK2 (TRKB) receptor leads to activation of RAS signaling and downstream phosphorylation of ERK1 (MAPK3) and ERK2 (MAPK1) (Chan et al. 2001). SOS1 functions as a guanine-nucleotide exchange factor for RAS proteins, catalyzing exchange of GDP for GTP, resulting in formation of the active RAS:GTP complex (Chardin et al. 1993).

SHC1介导的GRB2:SOS1至激活的NTRK2（TRKB）受体的募集导致RAS信号通路激活以及下游ERK1（MAPK3）和ERK2（MAPK1）的磷酸化（Chan等，2001年）。SOS1作为RAS蛋白的鸟苷酸交换因子，催化GDP与GTP的交换，从而形成活性RAS:GTP复合物（Chardin等，1993年）。