THE EFFECT OF BISPHOSPHONATES ON BONE REGENERATION IN PATIENTS WITH MULTIPLE MYELOMA

This study analyzes the clinical efficacy of bisphosphonates (zoledronic acid) in managing bone destruction associated with multiple myeloma, highlighting their role in both inhibiting osteoclastic resorption and stimulating reparative bone regeneration. The findings confirm that bisphosphonate therapy increases bone mineral density and significantly reduces the risk of pathological fractures. These conclusions demonstrate the strategic importance of this therapy in preventing complications and enhancing the quality of life for patients.本研究针对双膦酸盐（bisphosphonates）类药物中的唑来膦酸（zoledronic acid），分析其用于治疗多发性骨髓瘤（multiple myeloma）相关骨破坏的临床疗效，着重阐明其既可抑制破骨细胞吸收（osteoclastic resorption），又能促进修复性骨再生的双重作用。 研究结果证实，双膦酸盐疗法可提升骨矿物质密度（bone mineral density），并显著降低病理性骨折（pathological fractures）的发生风险。 上述结论彰显了该疗法在预防并发症、改善患者生活质量方面的重要临床策略价值。