Gene expression profile at single cell level from hippocampus of wild type mice and Camk2a-Vps13D KO mice

The failure to clear mitochondria, cell death and inflammation have been linked in neurodegenerative disease, but the relationship and role of inflammation in these conditions is not fully understood.To investigate it, we established a model for neurodegeneration caused by mitochondrial impairment by removing Vps13D from the hippocampus.We use single cell RNA sequencing to analyze the gene expression profile of wild type mice and Camk2a-Vps13D KO mice. Hippocampus single cell suspensions from wild type mice and Camk2a-Vps13D KO mice were used to generate scRNA-seq libraries with Chromium Next GEM Single Cell 3' Reagent Kits v3.1.