Influenza networks were used to interrogate PB2 interactors (tabs a and b) or proteins with known interactors important for IAV replication (PKR, RIG-I, CRM1, NXF1, EXOSC3, and UBR4; tabs c and d). PB
There are many well-known examples of proteins with low sequence similarity, adopting the same structural fold. This aspect of sequence-structure relationship has been extensively studied both experim
The drug-disease bipartite network used in the paper, which includes 18,317 drug-protein interactions between 813 unique drugs and 3,660 unique proteins. (XLSX 440 kb)
Amino acids committed to a particular function correlate tightly along evolution and tend to form clusters in the 3D structure of the protein. Consequently, a protein can be seen as a network of co-ev
Additional file 10. Web session interactive view with data table of STRING network for all comparison pairs with 25 additional database derived proteins. For description and legend refer to Fig. 7.
