Uptake of [³H(G)]pentamidine into brain tissue (corrected for vascular/[¹⁴C]sucrose space) and CSF (corrected for blood/[¹⁴C]sucrose contamination)at 2 hours post-injection in BALB/c mice.

Data is presented (a) as the tissue/plasma ratio and converted into concentrations in ng/g of tissue (b) and as concentration for the terminal plasma and CSF samples (c). A limitation of measuring pentamidine by scintillation counting is that any metabolites produced during the 2 hours that have retained the radiolabel, will be counted as [3H(G)]pentamidine. These metabolites may have different transport characteristics and may or may not be active against trypanosomes.