Actual and potential drug interactions of psychotropic drugs in patients of the covid-19 medicine service of the Hospital de Emergencia-Lima,2021

<strong>Background:</strong> Actual and potential drug-drug interactions of psychotropic drugs in patients of the COVID-19 Medicine Service of the Villa El Salvador Emergency Hospital during the months of February to July 2021. <strong>Methods:</strong> The study is deductive, retroprospective, quantitative, applied, cross-sectional observational. The instrument used was a collection card for 86 pharmacotherapeutic follow-ups where psychotropic drugs for anxiety, depression and insomnia were registered. <strong>Results:</strong> In the actual and potential drug interactions of psychotropic drugs, according to the degree of severity dimension, it was identified that the important indicator represented the highest frequency of 89% of the interactions; according to the type of interaction dimension, it was identified that the pharmacodynamic indicator presented a higher frequency with 53%; according to the clinical evidence dimension, it was identified that the fair indicator had a higher frequency with 73% interactions; in the manifestation dimension, it was identified that the potential indicator presented a higher frequency with 92.2% interactions. In its moment of appearance dimension, it was identified that the quick indicator had a higher prevalence with 5.5% of real interactions. In its causality algorithm dimension, the probable indicator was identified as having the highest frequency with 7.25% of actual interactions. With respect to sex, the male presented 49.9% of potential interactions and in the real interactions, the female sex presented a higher incidence with 4.3% interactions. The average age of the potential interactions was 48.83 years, and the average age of the real interactions was 45.67 years. Sertraline presented 53.2% of potential interactions and in relation to real drug interactions the one that presented the highest frequency was mirtazapine with 3.5% interactions.**背景**：2021年2月至7月期间，埃尔萨尔瓦多急诊医院新冠内科收治患者所使用精神药物（psychotropic drugs）的实际与潜在药物相互作用（drug-drug interactions）情况。 **研究方法**：本研究为演绎性、回顾性、定量、应用型横断面观察研究。研究工具为86份药物治疗随访记录卡，用于登记用于焦虑、抑郁及失眠治疗的精神药物。 **研究结果**：针对精神药物的实际与潜在药物相互作用，按严重程度维度分析，以“重要”等级为代表的相互作用占比最高，达89%；按相互作用类型维度分析，以药效学（pharmacodynamic）相互作用为代表的类型占比最高，为53%；按临床证据维度分析，以“一般”等级为代表的相互作用占比最高，达73%；按表现形式维度分析，以“潜在”表现为代表的相互作用占比最高，为92.2%。在出现时机维度中，以“快速出现”为代表的实际相互作用占比最高，达5.5%。在因果关系算法维度中，以“可能因果”为代表的实际相互作用占比最高，达7.25%。按性别划分来看，潜在药物相互作用中男性患者占比49.9%；而实际药物相互作用中，女性患者占比更高，达4.3%。潜在药物相互作用对应的患者平均年龄为48.83岁，实际药物相互作用对应的患者平均年龄为45.67岁。舍曲林（Sertraline）相关的潜在药物相互作用占比达53.2%；在实际药物相互作用中，米氮平（mirtazapine）相关相互作用占比最高，为3.5%。