Synthesis and cyclization of benzothiazole: review

Benzoheterocycles such as benzothiazoles, benzimid azoles and benzoxazoles can serve as unique and versatile scaffolds for experimental drug design. Among the all benzohaterocycles, benzothiazole has considerable place in research area especially in synthetic as well as inpharmaceutical chemistry because of its potent and significant pharmacological activities. Since, awide range of methods are available for synthesizing benzothiazole nucleus and its derivatives but areal need exists for new procedures that support many kinds of structural diversity and varioussubstitution. The present review deals with the common methods adopted and reported to focus thesynthesis as well as cyclisation of benzothiazole nucleus.