2-year Mortality and Dynamics in Patients with Chronic Disorders of Consciousness

The objective of this study was to first time in Russian Federation collect data on the survival and the level of consciousness of patients with chronic disorders of consciousness (cDOC), and based on them search for prognostic markers of survival and positive dynamic of the level of consciousness on long-terms outcomes (up to 24 months). All patients (n=184) had a diagnosis of cDOC and were admitted to Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology after anoxic brain injury (n = 52), vascular lesions (n = 50), traumatic brain injury (n = 74), and other causes (n=8). Our research showed that the survival rate (less then 30 %) and the rate of consciousness recovery (5 %) are both low, though not differ seriously from existing data for this category of patients. We hope, that the data obtained can aid in choosing the vector of further medical and social way of each cDOC patient and design appropriate measures to help the patient himself and, what can be equally important, his relatives.

本研究的目的为首次在俄罗斯联邦收集慢性意识障碍（chronic disorders of consciousness, cDOC）患者的生存状况与意识水平数据，并基于此类数据探索影响患者生存以及最长24个月长期结局中意识水平正向转归的预后标志物。本研究纳入的184例患者均确诊为慢性意识障碍，且均因缺氧性脑损伤（52例）、血管病变（50例）、创伤性脑损伤（74例）及其他病因（8例）入住重症医学与康复学联邦研究临床中心。研究结果显示，该类患者的生存率（低于30%）与意识恢复率（5%）均处于较低水平，但与该类患者的现有临床数据无显著差异。本研究所得数据有望为每一位慢性意识障碍患者后续的医疗与社会照护路径选择提供参考，并助力制定适配的患者帮扶措施——同样重要的是，也可为其家属提供相应支持。