Changes in the water dynamics of lung cells (A549 cell line) induced by Tocilizumabe

Through this proposal, we will achieve a much better understanding on the behaviour of water molecules of cells before and after being treated by the drug tocilizumabe (TCZ) either free or incorporated in the newly developed polymeric nanoparticles. Using TOSCA we will be able to uniquely correlate changes on the mobility of cellular water with the biological outcomes led by the drug.