Resveratrol loaded chitosan-pectin core-shell nanoparticles as novel drug delivery vehicle for sustained release and improved antioxidant activities

Resveratrol, chemically known as 3, 5, 4'-trihydroxy-trans-stilbene, is a natural polyphenol with promising multi-targeted health benefits. The optimal therapeutic uses of resveratrol are limited due to its poor solubility, rapid metabolism and low bioavailability. To address the issues, we have encapsulated resveratrol inside the nanosized core made of chitosan and coated this core with pectin - shell in order to fabricate a drug delivery vehicle which can entrap resveratrol for a longer period of time. The core - shell nanoparticles fabricated in this way were characterized with the help of Fourier Transform Infrared Spectrometer (FTIR), Field Emission Scanning Electron Microscope (FESEM), Field Emission Transmission electron microscopy/Selected Area Electron Diffraction (FETEM/SAED), High-Resolution Transmission Electron Microscope (HRTEM)), Dynamic Light Scattering (DLS) and Zeta Potential measurements. In vitro drug release study showed the ability of the core-shell nanoparticles t...

白藜芦醇（Resveratrol），化学名称为3,5,4'-三羟基反式二苯乙烯，是一种天然多酚类物质，具备多靶点调控机体健康的良好应用前景。然而其溶解性差、代谢速率快且生物利用度低，限制了白藜芦醇的最优临床治疗应用。为解决上述问题，本研究将白藜芦醇包封于壳聚糖（chitosan）制备的纳米级核芯内部，并以果胶作为外壳对该核芯进行包覆，以此构建可长时间包载白藜芦醇的药物递送载体。本研究通过傅里叶变换红外光谱仪（Fourier Transform Infrared Spectrometer, FTIR）、场发射扫描电子显微镜（Field Emission Scanning Electron Microscope, FESEM）、场发射透射电子显微镜/选区电子衍射（Field Emission Transmission Electron Microscopy/Selected Area Electron Diffraction, FETEM/SAED）、高分辨透射电子显微镜（High-Resolution Transmission Electron Microscope, HRTEM）、动态光散射（Dynamic Light Scattering, DLS）以及Zeta电位测试，对所制备的核壳纳米颗粒进行了表征。体外药物释放研究表明，该核壳纳米颗粒t……