A dataset of human and Plasmodium falciparum genotypes in severe malaria cases from The Gambia and Kenya

This data release contains human and <em>Plasmodium falciparum</em> malaria genotypes from the article: <strong>Malaria protection due to sickle haemoglobin depends on parasite genotype</strong> Gavin Band, Ellen M. Leffler, Muminatou Jallow, Fatoumatta Sisay-Joof, Carolyne<br> M. Ndila, Alexander W. Macharia, Christina Hubbart, Anna E. Jeffreys, Kate Rowlands, Thuy<br> Nguyen, Sónia Gonçalves, Cristina V. Ariani, Jim Stalker, Richard D. Pearson, Roberto<br> Amato, Eleanor Drury, Giorgio Sirugo, Umberto d'Alessandro, Kalifa A. Bojang, Kevin<br> Marsh, Norbert Peshu, Joseph W. Saelens, Mahamadou Diakité, Steve M. Taylor10, David J.<br> Conway, Thomas N. Williams, Kirk A. Rockett, Dominic P. Kwiatkowski Nature (2021) doi: 10.1038/s41586-021-04288-3 <strong>bioRxiv link</strong>: doi.org/10.1101/2021.03.30.437659. The release contains genotypes from human and <em>Plasmodium falciparum</em> genetic variants, genotyped using blood samples from 4,171 children ascertained with severe symptoms of malaria at the Royal Victoria Teaching Hospital (now the Edward Francis Small Teaching Hospital), The Gambia, and from the Kilifi District Hospital (now Kilifi County Hospital), Kenya in the period 1995-2009. An accompanying set of association test summary statistics has also been released on Zenodo (doi: 10.5281/zenodo.5722497). Please see www.malariagen.net/resource/32 for full details of other resources associated with the above manuscript.本数据集发布包含人类与恶性疟原虫（Plasmodium falciparum）的疟疾基因型数据，其来源论文为《镰状血红蛋白介导的疟疾保护作用依赖于寄生虫基因型》，作者包括Gavin Band、Ellen M. Leffler、Muminatou Jallow、Fatoumatta Sisay-Joof、Carolyne M. Ndila、Alexander W. Macharia、Christina Hubbart、Anna E. Jeffreys、Kate Rowlands、Thuy Nguyen、Sónia Gonçalves、Cristina V. Ariani、Jim Stalker、Richard D. Pearson、Roberto Amato、Eleanor Drury、Giorgio Sirugo、Umberto d'Alessandro、Kalifa A. Bojang、Kevin Marsh、Norbert Peshu、Joseph W. Saelens、Mahamadou Diakité、Steve M. Taylor10、David J. Conway、Thomas N. Williams、Kirk A. Rockett、Dominic P. Kwiatkowski。该论文发表于《自然》（Nature）2021年，DOI：10.1038/s41586-021-04288-3；其bioRxiv预印本平台链接为：doi.org/10.1101/2021.03.30.437659。 本次发布的数据涵盖人类与恶性疟原虫的遗传变异基因型，这些基因型通过1995年至2009年间采集的血液样本完成基因分型，样本来自冈比亚皇家维多利亚教学医院（现爱德华·弗朗西斯·斯莫尔教学医院）以及肯尼亚基利菲地区医院（现基利菲县医院）招募的4171名确诊重症疟疾的患儿。 同步发布了配套的关联检验汇总统计数据集，该数据集已上传至Zenodo平台，DOI：10.5281/zenodo.5722497。如需了解该论文相关其他资源的完整详情，请访问官网www.malariagen.net/resource/32。