Differentially expressed ncRNAs derived from circulating exosomes in the pathogenesis of rat spinal cord injury

This study was originally designed to have a general overview of differentially expressed ncRNAs including miRNAs, circRNAs and lncRNAs, from circulating exosomes in SCI rats in comparison with the control rats. Rat SCI model is utilised and exosomes are collected. Exosomal circRNAs are obtained, functional enrichment analyses including KEGG pathway and GO ontology are performed, and several differentially expressed circRNAs are confirmed through RT-PCR. Furthermore, the interaction network of circRNA-miRNA-mRNA is constructed.