相关数据集
灵长类动物肝脏衰老的单核转录组图谱揭示了SREBP2在肝细胞中的促衰老作用
衰老会增加患肝脏疾病的风险和对衰老相关疾病的全身易感性。然而，高等脊椎动物的细胞类型特异性变化和肝脏衰老的潜在机制仍不完全表征。在这里，我们构建了灵长类动物肝脏衰老的第一个单核转录组景观，其中我们解决了三种肝细胞中细胞类型特异性基因表达的波动，并检测了肝细胞和生态位细胞之间的异常细胞间相互作用。在深入剖析这个丰富的数据集后，我们发现了脂质代谢受损和慢性炎症相关基因的上调，这些基因与衰老过程中肝功能
干细胞与再生医学数据中心2023-08-29 更新270
Comprehensive transcriptional profiling of porcine liver aging. Comprehensive transcriptional profiling of porcine liver aging
Aging is a major risk factor for the development of many diseases, and liver as the most important metabolic organ is significantly affected by aging. Earlier studies have shown that liver weight tend
NIAID Data Ecosystem60
Changes at the nuclear lamina alter binding of pioneer factor Foxa2 in aged liver.. Mus musculus
Increasing evidence suggests that regulation of heterochromatin at the nuclear envelope underlies metabolic disease susceptibility and age-dependent metabolic changes, but the mechanism is unknown. He
NIAID Data Ecosystem30
A senescent liver is rejuvenated in a young systemic environment: A study based on comparison of chronological and biological ages. A senescent liver is rejuvenated in a young systemic environment: A study based on comparison of chronological and biological ages
Though the liver plays central roles in metabolism, the pivotal biological events throughout its aging are still unknown, resulting in ambiguity as to whether liver senescence could be reversed. To es
NIAID Data Ecosystem70
Liver_clock
This repository contains the data to reproduce the result of the manuscript Rejuvenation of naturally aged mice by mesenchymal stem cells SHED treatment with affecting ribosomal and mitochondrial
DataCite Commons2022-08-18 更新50
