Zeolitic imidazolate frameworks (ZIF-8) as a carrier in a topical ocular delivery system for the treatment of ocular diseases

Current systems for topical ocular drug delivery enable non-invasive administration of therapeutics to the eye but suffer from poor permeability and bioavailability, limiting therapeutic efficacy. Metal-organic frameworks are porous, crystalline materials that can serve as drug delivery systems and may improve these shortcomings. In this study, we explore the use of ZIF-8 as a representative metal-organic framework for topical ocular drug delivery. ZIF-8 particles were prepared via a simplified aqueous synthetic method and loaded with ovalbumin, a model molecule to simulate anti-angiogenic proteins that are used to treat retinal diseases. The physical properties of unloaded and loaded ZIF-8 were evaluated with a variety of spectroscopic, imaging, and desorption techniques that confirmed successful loading with ovalbumin (>46% loading capacity) without severe disruption to the structure of ZIF-8. In a bulk solution, loaded ovalbumin is gradually released in a linear fashion for up to ..., , # Data from: Zeolitic imidazolate frameworks (ZIF-8) as a carrier in a topical ocular delivery system for the treatment of ocular diseases Dataset DOI: [10.5061/dryad.rv15dv4p6](https://doi.org/10.5061/dryad.rv15dv4p6) ## Description of the data and file structure This study highlights the potential of ZIF-8 as a carrier in topical ocular delivery systems and provides a crucial foundation to evaluate its efficacy in topical ocular drug delivery using in vivo models. ### Files and variables #### File: S4-PXRD_data_blank.csv **Description:**Â Powder X-ray diffration (PXRD) data for unloaded ZIF-8. X=2 theta (degrees); Y=intensity (AU) #### File: S4-PXRD_data.csv **Description:**Â Powder X-ray diffraction (PXRD) data for ovalbumin-loaded ZIF-8. X=2 theta (degrees); Y=intensity (AU) #### File: S5-FTIR_data_blank.csv **Description:**Â Fourier transform infrared (FTIR) spectroscopy for unloaded ZIF showing wavelength and transmittance. Data are also shown adjusted for absorbance at bas..., ,当前用于眼部局部给药的系统可实现治疗药物的无创眼部给药，但存在渗透性差、生物利用度低的问题，从而限制了治疗效果。金属有机框架（metal-organic frameworks, MOFs）是一类多孔晶态材料，可作为药物递送载体，有望改善上述缺陷。本研究选取ZIF-8作为典型的金属有机框架材料，用于眼部局部给药递送系统的探索。本研究通过简化水相合成法制备ZIF-8颗粒，并以卵清蛋白作为模拟分子负载于ZIF-8之上，该模拟分子用于模拟治疗视网膜疾病的抗血管生成蛋白。研究人员通过多种光谱学、成像及脱附技术，对未负载及负载卵清蛋白的ZIF-8的物理性质进行表征，结果证实卵清蛋白成功负载（负载率＞46%），且未对ZIF-8的结构造成严重破坏。在本体溶液中，负载的卵清蛋白可呈线性方式逐步释放，时长可达……。# 数据来源：沸石咪唑酯框架（zeolitic imidazolate frameworks, ZIF-8）作为眼部局部递送系统载体用于眼科疾病治疗 数据集DOI：10.5061/dryad.rv15dv4p6，访问链接：https://doi.org/10.5061/dryad.rv15dv4p6 ## 数据与文件结构说明 本研究证实了ZIF-8作为眼部局部递送系统载体的应用潜力，为通过体内模型评估其在眼部局部给药中的疗效提供了重要基础。 ### 文件与变量 #### 文件：S4-PXRD_data_blank.csv **描述：** 未负载ZIF-8的粉末X射线衍射（powder X-ray diffraction, PXRD）数据。X轴为2θ角（单位：度）；Y轴为衍射强度（单位：任意单位，AU） #### 文件：S4-PXRD_data.csv **描述：** 负载卵清蛋白的ZIF-8的粉末X射线衍射（PXRD）数据。X轴为2θ角（单位：度）；Y轴为衍射强度（单位：任意单位，AU） #### 文件：S5-FTIR_data_blank.csv **描述：** 未负载ZIF-8的傅里叶变换红外（Fourier transform infrared, FTIR）光谱数据，包含波长与透光率信息。数据同时已针对基线处的吸光度进行校正……