Data from: Odd-paired controls frequency doubling in Drosophila segmentation by altering the pair-rule gene regulatory network

The Drosophila embryo transiently exhibits a double segment periodicity,
defined by the expression of seven "pair-rule" genes, each in a
pattern of seven stripes. At gastrulation, interactions between the
pair-rule genes lead to frequency doubling and the patterning of fourteen
parasegment boundaries. In contrast to earlier stages of Drosophila
anteroposterior patterning, this transition is not well understood. By
carefully analysing the spatiotemporal dynamics of pair-rule gene
expression, we demonstrate that frequency-doubling is precipitated by
multiple coordinated changes to the network of regulatory interactions
between the pair-rule genes. We identify the broadly expressed but
temporally patterned transcription factor, Odd-paired (Opa/Zic), as the
cause of these changes, and show that the patterning of the even-numbered
parasegment boundaries relies on Opa-dependent regulatory interactions.
Our findings indicate that the pair-rule gene regulatory network has a
temporally-modulated topology, permitting the pair-rule genes to play
stage-specific patterning roles.