Clinical characteristics of patients whose tumors contained a somatic mutation.

Smoking history is defined as never smokers (<100 lifetime cigarettes), former smokers (quit ≥1 year prior to diagnosis), or current (quit <1 year prior to diagnosis. Former smokers were further defined as having smoked ≤15 pack years (number of packs of cigarettes smoked per day multiplied by the number of years the person has smoked) or >15 pack years. 1Mutation previously reported (5). 2Tumor contained both a KRAS and PIK3CA mutation. Abbreviations: ADENO, adenocarcinoma; AWBF, adenocarcinoma with bronchioalveolar features (38); SCC, squamous cell carcinoma; dup, duplication; del, deletion. AWBF is equivalent to the WHO classification: adenocarcinoma, mixed subtype, with BAC component (39).