Preparation of dihydroartemisinin-sodium taurocholate PLGA nanoparticles and its anti-Echinococcus granulosus activity

To develop liver-targeted DHA-STC-PLGA (DSP) nanoparticles with effective therapeutic effects against Echinococcus granulosus, this study first optimizes the preparation process of DSP nanoparticles using the response surface methodology (RSM) and evaluates their characterization, stability, and encapsulation efficiency. Then, the safety of DSP is assessed by oral administration in mice, followed by an evaluation of its therapeutic effects in a Echinococcus granulosus-infected mouse model. Finally, in vitro experiments, including transcriptomic analysis and qPCR, are conducted to elucidate the antiparasitic mechanism of DSP.