Demographics and clinical characteristics of the control subjects and RRMS patients.

Note: M = male; F = female; TWMLL = total white matter lesion loads; BPF = brain parenchymal fraction; EDSS = expanded disability status scale; PASAT = paced auditory serial addition test; MFIS = modified fatigue impact scale;*The measurement procedures for TWMLL and BPF in the RRMS patients have been previously described by [37] and [38], respectively (see Figure S1 and Supporting Information S1).