Exceptional origin activation revealed by comparative analysis in two laboratory yeast strains

We mapped ssDNA formation in WT and rad53K227A cells in both A364a and W303 background. We also performed whole genome sequencing of the A364a strain.我们在A364a与W303两种遗传背景下，针对野生型（Wild Type, WT）及rad53K227A突变细胞中的单链DNA（single-stranded DNA, ssDNA）形成事件完成了图谱绘制。此外，我们还对A364a菌株进行了全基因组测序。