Metastatic potential in clonal melanomal cells is driven by a rare, early-invading subpopulation [ATAC-Seq]

To investigate the molecular basis driving a highly invasive phenotype of a rare subpopulation of melanoma cells; The highly invasive phenotype was regulated by the NKX2.2 transcription factor and it was marked by transiently high levels of SEMA3C. We performed analysis of chromatin accessibility changes using data obtained from ATAC-seq of FS4 and 1205Lu melanoma cell lines.