Association of significant SNPs in the steroid hormone biosynthesis pathway and PGR with gastric cancer risk (discovery phase).

aChromosome.bMinor allele frequency.cAll raw p-values calculated with 1 degree of freedom in additive model except rs1902580, rs10519301.dRs1902580, rs10519301 raw p-values calculated with 1 degree of freedom in recessive model.eAdjusted for age, smoking, history of H. pylori infection, and CagA infection.fPermutated p-values calculated from 10,000 permutations in the single SNP analysis in the additive model.gSNPs selected for the extension analysis. For PGR, one haploblock created and thus SNP selected according to the following criteria: 1) SNPs on coding or 3UTR region; 2) lower raw p-value and permutated p-valueCYP19A1, six haploblocks created and significant SNPs in discovery phase were located in the blocks 4, 5, and 6. SNP selection for the extension phase was one or more of the following: 1) lower raw p-value and permutated p-valuehAll FDR p-values>0.05.