Somatic_mutations_in_normal_murine_tissue. Somatic_mutations_in_normal_murine_tissue

Cancer is driven by mutation. Using Agilent exome hybridisation capture and Illumina massively parallel sequencing technology, we aim to sequence microRNAs plus the protein coding genome of a number of samples. Bespoke algorithms are being developed to identify the somatically acquired point mutations, insertions and deletions in these samples. This project will give unprecedented insights into mutational processes, cellular repair pathways and gene networks associated with cancer development.