We used microarrays to detail the global programme of gene expression after 4 months of TFEB overexpression in the brain. Groups of Tg4510 and Wild-type mice were injected at P0 in the brain. Those gr
IntroductionRestrictions on existing APOE mouse models have impacted research toward understanding the strongest genetic risk factor contributing to Alzheimer’s disease (AD) and dementia, APOEε4, by h
RNA was purified from frozen fusiform gyrus tissue sections of autopsy-confirmed Alzheimer's cases and neurologically normal age-matched controls. 89 of the 289 subjects in this study were previously
Recent concerns have been raised regarding high folate intake during pregnancy and lactation, particularly following food fortification and increased vitamin supplement use. Epidemiologic studies have