<b>Mediating Role of Plasma Metabolites in the Gut Microbiota-Macular Degeneration Axis: Insights from Mendelian Randomization</b>

Table S1: Instrumental variables of gut microbiota after clumping and exclusion of week IVs; Table S2: Instrumental variables of plasma metabolites after clumping and exclusion of week IVs; Table S3: Causal effects of gut microbiota on MD (Forward MR analysis); Table S4: Causal effects of MD on identified gut microbiota (Reverse MR analysis); Table S5: Genetic correlation between identified gut microbiota and MD (LDSC analysis); Table S6: Causal associations between plasma metabolites and MD (Associations only with PIVW less than 0.05 and consistent with all sensitivity analysis were listed); Table S7: Causal associations between identified gut microbiota and 35 plasma metabolites; Table S8: Mediation analysis between gut microbiota, plasma metabolites, and MD.