Differential expression profile of liver fibrosis rats induced by CCl4

This study aimed to investigate the protective mechanisms of helenalin on hepatic fibrosis,Rats were intragastrically administrated with 50% CCl4 for 9 weeks to induce liver fibrosis, followed by various medicines for 6 weeks. The transcriptomic analysis was performed in liver tissues by RNA-seq. Overall design: the rats were randomly divided into several groups: the model group and helenalin-treated groups were administered with CCl4 to induce liver fibrosis, followed by various agents.