File S1 - Electrophysiological and Structural Remodeling in Heart Failure Modulate Arrhythmogenesis. 1D Simulation Study

Figure S1, Random configurations for 10% fibrosis in the multicellular strand. The multicellular strand is composed by 165 nodes, where the fibroblast model is solved in 10% of the nodes (light color) and the myocyte AP model is solved in the rest of the nodes (blue). See Methods for details. Figure S2, Random configurations for 20% fibrosis in the multicellular strand. The multicellular strand is composed by 165 nodes, where the fibroblast model is solved in 20% of the nodes (light color) and the myocyte AP model is solved in the rest of the nodes (blue). See Methods for details. Figure S3, APD dispersion for normal coupling. Boxplots showing action potential duration (ADP) dispersion for low fibrosis (10%) and high fibrosis (20%), and DM = 0.0006 cm/ms. Figure S4, TDR for normal coupling. Boxplots showing transmural dispersion (TDR) for low fibrosis (10%) and high fibrosis (20%), and DM = 0.0006 cm/ms. Figure S5, APD dispersion for severe uncoupling. Boxplots showing action potential duration (ADP) dispersion for low fibrosis (10%) and high fibrosis (20%), and DM = 0.00025 cm/ms. Figure S6, TDR for severe uncoupling. Boxplots showing transmural dispersion (TDR) for low fibrosis (10%) and high fibrosis (20%), and DM = 0.00025 cm/ms. Figure S7, APD dispersion for intermediate uncoupling. Boxplots showing action potential duration (ADP) dispersion for low fibrosis (10%) and high fibrosis (20%), and DM = 0.0003 cm/ms. Figure S8, TDR for intermediate uncoupling. Boxplots showing transmural dispersion (TDR) for low fibrosis (10%) and high fibrosis (20%), and DM = 0.0003 cm/ms. Figure S9, APD dispersion for mild uncoupling. Boxplots showing action potential duration (ADP) dispersion for low fibrosis (10%) and high fibrosis (20%), and DM = 0.00045 cm/ms. Figure S10, TDR for mild uncoupling. Boxplots showing transmural dispersion (TDR) for low fibrosis (10%) and high fibrosis (20%), and DM = 0.00045 cm/ms. Table S1, APD dispersion and TDR for 10% fibrosis. Action potential duration (APD) dispersion and transmural dispersion (TDR) for the random configurations corresponding to a fibrotic content of 10% and normal intercellular coupling (DM = 0.0006 cm/ms). Table S2, APD dispersion and TDR for 20% fibrosis. Action potential duration (APD) dispersion and transmural dispersion (TDR) for the random configurations corresponding to a fibrotic content of 20% and normal intercellular coupling (DM = 0.0006 cm/ms). Table S3, APD dispersion for 10% fibrosis and intercellular uncoupling. Action potential duration (APD) dispersion for the random configurations corresponding to a fibrotic content of 10% and several degrees of intercellular uncoupling (DM in cm/ms). Table S4, TDR for 10% fibrosis and intercellular uncoupling. Transmural dispersion of repolarization (TDR) for the random configurations corresponding to a fibrotic content of 10% and several degrees of intercellular uncoupling (DM in cm/ms). Table S5, APD dispersion for 20% fibrosis and intercellular uncoupling Action potential duration (APD) dispersion for the random configurations corresponding to a fibrotic content of 20% and several degrees of intercellular uncoupling (DM in cm/ms). Table S6, TDR for 20% fibrosis and intercellular uncoupling. Transmural dispersion of repolarization (TDR) for the random configurations corresponding to a fibrotic content of 20% and several degrees of intercellular uncoupling (DM in cm/ms). (DOCX)