1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) as target for anti Toxoplasma gondii compounds: crystal structure, biochemical characterization and biological evaluation of inhibitors

1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) as target for anti Toxoplasma gondii compounds: crystal structure, biochemical characterization and biological evaluation of inhibitors Descriptor: 1-deoxy-D-xylulose-5-phosphate reductoisomerase, 3-[FORMYL(HYDROXY)AMINO]PROPYLPHOSPHONIC ACID, CHLORIDE ION, ... Authors: Mazzone, F, Hoeppner, A, Reiners, J, Applegate, V, Abdullaziz, M, Gottstein, J, Wesemann, M, Kurz, T, Smits, S.H, Pfeffer, K. Deposit date: 2024-02-26 Release date: 2024-08-21 Last modified: 2024-09-04 Method: SOLUTION SCATTERING (2.56 Å), X-RAY DIFFRACTION Cite: 1-Deoxy-d-xylulose 5-phosphate reductoisomerase as target for anti Toxoplasma gondii agents: crystal structure, biochemical characterization and biological evaluation of inhibitors. Biochem.J., 481, 2024以1-脱氧-D-木酮糖5-磷酸还原异构酶（1-deoxy-D-xylulose 5-phosphate reductoisomerase，DXR）为抗刚地弓形虫（Toxoplasma gondii）化合物靶点：抑制剂的晶体结构、生化表征与生物学评价 描述项：1-脱氧-D-木酮糖5-磷酸还原异构酶、3-[甲酰基(羟基)氨基]丙基膦酸、氯离子（CHLORIDE ION）等 作者：Mazzone F、Hoeppner A、Reiners J、Applegate V、Abdullaziz M、Gottstein J、Wesemann M、Kurz T、Smits S.H、Pfeffer K 存库日期：2024-02-26 发布日期：2024-08-21 最后修改日期：2024-09-04 研究方法：溶液散射（SOLUTION SCATTERING，分辨率2.56 Å）、X射线衍射（X-RAY DIFFRACTION） 引用文献：《1-脱氧-D-木酮糖5-磷酸还原异构酶作为抗刚地弓形虫制剂靶点：抑制剂的晶体结构、生化表征与生物学评价》，《Biochem.J.》，第481卷，2024年