ATAC Sequencing Facilitates the Role of Nuclear Protein DEK in Regulating Chromatin Accessibility of Hematopoietic Stem Cells [ATAC-seq]
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https://www.ncbi.nlm.nih.gov/sra/SRP305491
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Purpose:To identify genes involved in the DEK regulating chromatin accessibility of hematopoietic stem cells (HSC) in mice, we performed ATAC-Sequence of HSC freshly sorted from mice. Overall design: Methods: About 20,000 HSC (Lin-Sca-1+c-Kit+CD48-CD150+) were isolated by FACS from Dekfl/fl (floxp) and Dekfl/fl,Tie2-Cre (cKO). Genomic DNA profiles of HSC treated with Tn5 enzyme were generated by deep sequencing, in duplicate, using Illumina HiSeq 2000.
创建时间：
2021-05-25
