mir-124 predicted interactions with cell cycle and differentiation

Schematic of predicted interactions of miR-124 with cell cycle and cell differentiation machinery. A genomewide miRNA mimic toxicity screen indicates common and selective vulnerabilities of epithelial ovarian cancer cells. miR-124 is selectively toxic, mainly by inducing terminal cell differentiation via its target SIX4.

miR-124与细胞周期及细胞分化机制预测性交互作用图示。全基因组miRNA模拟毒性筛选揭示了上皮性卵巢癌细胞普遍且具有选择性的脆弱性。miR-124具有选择性毒性，主要通过靶向SIX4诱导细胞终末分化实现。