Plasmodium falciparum GCN5-TY1 ChIPseq and GCN5 knockout RNAseq and Pf H2B.Zac ChIPseq

The malaria parasite P. falciparum regulates gene expression and chromatin structure through modifying the histones within nucleosomes. This study analysed the histone acetyl transferase PfGCN5 by determining its sites of enrichment within the genome and the effect on gene expression and acetylation of the histone Pf H2B.Z when PfGCN5 was knocked-out. PfGCN5 is essential for parasite survival and is a potential drug target and this study provided information on PfGCN5 function relevant to its investigation as a drug target.