Methylomic analysis of ovarian cancers identifies tumor-specific alterations readily detectable in early precursor lesions

High-grade serous ovarian carcinoma (HGSOC) typically remains undiagnosed until advanced stages when peritoneal dissemination has already occurred. Here, we sought to identify HGSOC-specific alterations in DNA methylation and assess their potential to provide sensitive and specific detection HGSOC at its earliest stages. MethylationEPIC genome-wide methylation analysis was performed on a cohort comprising 23 HGSOC, 37 non-HGSOC malignant and 36 cancer-free fresh-frozen gynecologic tissue samples. Please note that the records have been updated with the raw data IDAT files on Mar 01, 2024.