Additional Supplement Data of the manuscript "Epigenome-Wide Association Study of Asthma Exacerbations in Europeans"

For this manuscript we conducted an epigenome-wide association study of asthma exacerbations following a discovery and validation design. The discovery phase includes GEMAS study, which is divided into two subsets (312 Canary Islanders and 94 Basques). Separately summary statistics are avaliable for each subset: "25_EWAS_GEMAS_EPIC_Exacerbations_mval_lineal_age-sex-batch-pcs-ccReFACTor_filtered.txt" for Canary Islanders and "25_EWAS_GEMAS_PV_EPIC_Exacerbations_mval_lineal_age-sex-batch-pcs-ccReFACTor_filtered.txt" for Basques including the following columns: probes: Probe ID logFC: estimate of the log2-fold-change corresponding to the effect SE: standard error CI.L: left limit of confidence interval for logFC CI.R: right limit of confidence interval for logFC t: moderated t-statistic P.Value: raw p-value adj.P.Val: adjusted p-value by false discovery rate CHR: chromosome pos: genomic position based on hg38/GRCh38 UCSC_RefGene_Name: gene annotation based on Illumina EPIC Manifest file v 1.0 B4 In addition, we performed a meta-analysis whose results summary statistics output is organized in the following columns: RSID: Probe ID STUDY: number of studies or subsets were is present the probe BETA_meta: coefficient estimate SEBETA_meta: standard error PVALUE_meta: raw p-value PVALUE_Q: p-value of Cochran’s Q Model: FE (fixed effect) or RE2 (random effect) PVALUE_meta_adj: adjusted p-value by false discovery rate本研究针对哮喘急性加重开展表观基因组全关联研究（Epigenome-Wide Association Study，EWAS），采用发现-验证研究设计。发现阶段纳入GEMAS研究，该研究分为两个亚组：312名加那利群岛居民与94名巴斯克人。为每个亚组分别提供了独立的汇总统计数据：针对加那利群岛居民的文件为"25_EWAS_GEMAS_EPIC_Exacerbations_mval_lineal_age-sex-batch-pcs-ccReFACTor_filtered.txt"，针对巴斯克人的文件为"25_EWAS_GEMAS_PV_EPIC_Exacerbations_mval_lineal_age-sex-batch-pcs-ccReFACTor_filtered.txt"，两类文件均包含以下列： 探针ID（Probe ID）：探针标识符； logFC：对应效应的log₂倍变化估计值； SE：标准误（Standard Error）； CI.L：log₂倍变化的置信区间左边界； CI.R：log₂倍变化的置信区间右边界； t：调节t统计量（Moderated t-statistic）； P.Value：原始P值； adj.P.Val：经错误发现率（False Discovery Rate）校正的P值； CHR：染色体（Chromosome）； pos：基于hg38/GRCh38参考基因组的基因组位置； UCSC_RefGene_Name：基于Illumina EPIC芯片注释文件v1.0 B4的基因注释； 此外，本研究开展了荟萃分析，其结果的汇总统计文件包含以下列： RSID：探针ID（Probe ID）； STUDY：该探针所涉及的研究/亚组数量； BETA_meta：荟萃分析系数估计值； SEBETA_meta：标准误； PVALUE_meta：原始P值； PVALUE_Q：科克伦Q检验P值； Model：模型类型，包括FE（固定效应模型，Fixed Effect）与RE2（随机效应模型，Random Effect）； PVALUE_meta_adj：经错误发现率校正的荟萃分析P值