Genetic variations in APOBEC3 genes between and within chimpanzee (sub)species.

a, position of the variant on the chimpanzee reference genome panTro3; chr22, chromosome 22.b, position of the nucleotide variant within the gene; REF, nucleotide found on panTro3 reference genome; ALT, variant; equal sign, synonymous change.c, position of the corresponding amino acid within the protein. Underlined SNPs were functionally tested (Fig 4).d, summary of the individuals bearing the variant; Pp, Pan paniscus; Pts, Pan troglodytes schweinfurthii; Ptt, P. t. troglodytes; Pte, P. t. ellioti; Ptv, P. t. verus.e, total number of individuals homozygous for the reference.f, total number of individuals heterozygous.g, total number of individuals homozygous for the variant.Single nucleotide variants found in coding regions of the four antiviral APOBEC3 genes of the Pan genus. The variants that were tested in functional assays are underlined.