Affective Control of Decision Making

The dataset contains the raw and primary data associated to the project Affective Control of Decision Making (ACoDM). This project has received funding from the European Union’s Horizon 2020 research and innovation programme, Grant No 867424. Below we supply information on the provided metadata, which refer to individual raw files, and details on the specific data formats used. For further explanation please refer to the file DataSet0_Overview.rtf. The aim of this research is to understand affective aspects of circuit mechanisms underlying decision-making. Specifically, the functions of the amygdalostriatal and amygdalocortical pathways in an approach-avoidance conflict and the circuit mechanisms underlying the activation of such pathways. While trying to understand this, we performed three sets of experiments. The <strong>first objective</strong> is to differentiate the function of the basal amygda (BA) and the posterior striatum (pStr) in an approach-avoidance conflict. The <strong>second objective</strong> is to understanding potential behaviours and stimuli that might be affected by striatal function. The <strong>third objective</strong> is to understand the circuit mechanisms underlying the activation of amygdalostriatal (BA to dorsomedial striatum –DMS-) and amygdalocortical (BA to prelimbic cortex –PrL-) pathways in a risk-taking paradigm. This dataset is comprised by three sets of data: <strong> DATA SET 1.</strong> The function of the BA and pStr in decision making. <strong> DATA SET 2.</strong> Recording of the unitary activity in the pStr. <strong> DATA SET 3.</strong> The circuit mechanisms underlying the role of the BA input projection into targeting the DMS and Prelimbic cortex in decision making. <strong>DATASET1: The function of the BA and pStr in decision making</strong> The aim of this experiment is to uncover the contribution of the basal amygdala (BAa) and Striatum (Str) in a decision-making behavioural paradigm, the active avoidance protocol. This dataset consists of two experiments codenamed: <strong>Inhibition BAa</strong> and <strong>Inhibition Str</strong>. Files: <strong>DataSet1_InhibitionBAa_InjectionFiles.zip,</strong> Contains the images of the injection sites for the experiment InhibitionBAa. Data format: .jpg. <strong>Dataset1_InhibitionBAa_TrackTTL.zip, </strong>Contains the raw and primary data for the experiment InhibitionBAa. Data format: .mat, .mp4, .rhd. <strong>DataSet1_InhibitionStr_InjectionFiles.zip</strong>, Contains the images of the injection sites for the experiment InhibitionStr. Data format: .tif. <strong>Dataset1_InhibitionStr_TrackTTL.zip, </strong>Contains the raw and primary data for the experiment InhibitionStr. Data format: .mat, .mp4, .rhd. <strong>DataSet1_AnimalCodes.csv, </strong>List of the animals used in this dataset with codenames, genders and other relevant information. <strong>DataSet1_InhibitionBAaProtocol.rtf, </strong>Description of the behavioural protocol and acquired data for the experiment Inhibition BAa. <strong>DataSet1_InhibitionStrProtocol.rtf, </strong>Description of the behavioural protocol and acquired data for the experiment Inhibition Str. <strong>DataSet1_TissueData.csv, </strong>List and description of the injection images. <strong>DataSet1_WeightControl.csv, </strong>Weight loss supervision of the animals used in this dataset. <strong>DATASET2: Recording of the unitary activity in the pStr</strong> The aim of this experiment is to uncover the potential behaviours and stimuli that might be affected by striatal function. This dataset consists of an experiment with two protocols codenamed: <strong>Sound Protocol</strong> and <strong>Behaviour Protocol</strong>. Files: <strong>DataSet2_UnitsRecordingsStr_BehaviourProtocolData.zip, </strong>Contains the raw and primary data for the Behaviour Protocol. Data format: .mat, .mp4, .continuous, .csv, etc. <strong>DataSet2_UnitsRecordingsStr_ElectrodesLocation.zip,</strong> Contains the images of the track left by the penetration of the electrodes for each animal used in the experiment. Data format: .tif. <strong>DataSet2_UnitsRecordingsStr_SoundProtocolData.zip, </strong>Contains the raw and primary data for the Sound Protocol. Data format: .mat, .wmv, .continuous, .csv, etc. <strong>DataSet2_AnimalCodes.csv, </strong>List of the animals used in this dataset with codenames, genders and the list and description of the electrodes track images and other relevant information. <strong>DataSet2_ElectrodesGroups.csv, </strong>Detailed explanation of the grouping used to analyse the neurons in the Sound Protocol. <strong>DataSet2_NeuronsList.csv, </strong>List and detailed description of the neurons recorded in this dataset. <strong>DataSet2_UnitsRecordingsStr_BehaviourProtocol .rtf, </strong>Description of the behavioural protocol and acquired data for the Behaviour Protocol<strong>.</strong> <strong>DataSet2_UnitsRecordingsStr_SoundProtocol.rtf, </strong>Description of the behavioural protocol and acquired data for the Sound Protocol. <strong>DATASET3: The role of the BA input projection into DMS and PrL in decision making.</strong> The aim of this experiment is to uncover the mechanism by which the neural activity in the PrL and the DMS during a decision-making paradigm is controlled by the BA afferents. Files: <strong>DataSet3_GamblingTask_Data.zip, </strong>Contains the raw and primary data for the experiment. Data format: .mat, .continuous, .events, etc. <strong>DataSet3_GamplingTask_InjectionElectrodesLocation.zip,</strong> Contains the images of the track left by the penetration of the electrodes and the injection sites for each animal used in the experiment. Data format: .jpg. <strong>DataSet3_AnimalCodes.csv, </strong>List of the animals used in this dataset with codenames, genders and other relevant information. <strong>DataSet3_GamblingTask_NeuronsList.csv, </strong>List and detailed description of the neurons recorded in this dataset. <strong>DataSet3_GamblingTask_Protocol.rtf, </strong>Description of the behavioural protocol and acquired data for the experiment<strong>.</strong> <strong>DataSet3_TissueData.csv, </strong>List and description of the injection images. <em>All videos, TTLs, recordings and tracking are available on demand. Please contact pardo-bellver.cecilia(a)koki.hu.</em>本数据集包含与**决策情感控制（Affective Control of Decision Making, ACoDM）**项目相关的原始及一手数据。该项目获欧盟地平线2020（Horizon 2020）研究与创新计划资助，资助编号为867424。下文将提供与各原始文件对应的元数据信息，以及所用特定数据格式的详细说明。如需进一步解释，请参阅文件DataSet0_Overview.rtf。 本研究旨在阐明决策行为背后神经环路机制的情感层面，具体聚焦于趋避冲突情境中杏仁纹状体通路与杏仁皮层通路的功能，以及调控此类通路激活的神经环路机制。研究期间共开展三组实验，具体目标如下： 1. **首要目标**：区分基底杏仁核（basal amygdala, BA）与后纹状体（posterior striatum, pStr）在趋避冲突中的功能； 2. **次要目标**：明确可能受纹状体功能影响的潜在行为与刺激类型； 3. **第三目标**：阐明冒险任务范式中，杏仁纹状体通路（BA至背内侧纹状体——DMS）与杏仁皮层通路（BA至前边缘皮层——PrL）激活的神经环路机制。 本数据集包含三类数据： ### 数据集1：决策行为中BA与pStr的功能 本实验旨在揭示基底杏仁核（BA）与纹状体（Str）在主动回避范式这一决策行为任务中的作用。本数据集包含两项代号分别为**BA抑制（Inhibition BAa）**与**纹状体抑制（Inhibition Str）**的实验。 相关文件如下： - DataSet1_InhibitionBAa_InjectionFiles.zip：包含BA抑制实验的注射位点图像，数据格式为.jpg； - Dataset1_InhibitionBAa_TrackTTL.zip：包含BA抑制实验的原始与一手数据，数据格式为.mat、.mp4、.rhd； - DataSet1_InhibitionStr_InjectionFiles.zip：包含纹状体抑制实验的注射位点图像，数据格式为.tif； - Dataset1_InhibitionStr_TrackTTL.zip：包含纹状体抑制实验的原始与一手数据，数据格式为.mat、.mp4、.rhd； - DataSet1_AnimalCodes.csv：本数据集所用实验动物的代号、性别及其他相关信息列表； - DataSet1_InhibitionBAaProtocol.rtf：BA抑制实验的行为范式与采集数据说明文档； - DataSet1_InhibitionStrProtocol.rtf：纹状体抑制实验的行为范式与采集数据说明文档； - DataSet1_TissueData.csv：注射位点图像的列表与说明文档； - DataSet1_WeightControl.csv：本数据集实验动物的体重变化监测记录。 ### 数据集2：pStr的单位电活动记录 本实验旨在明确可能受纹状体功能影响的潜在行为与刺激类型。本数据集包含两项代号分别为**声音范式（Sound Protocol）**与**行为范式（Behaviour Protocol）**的实验。 相关文件如下： - DataSet2_UnitsRecordingsStr_BehaviourProtocolData.zip：包含行为范式实验的原始与一手数据，数据格式为.mat、.mp4、.continuous、.csv等； - DataSet2_UnitsRecordingsStr_ElectrodesLocation.zip：包含本实验各动物电极穿刺留下的追踪图像，数据格式为.tif； - DataSet2_UnitsRecordingsStr_SoundProtocolData.zip：包含声音范式实验的原始与一手数据，数据格式为.mat、.wmv、.continuous、.csv等； - DataSet2_AnimalCodes.csv：本数据集所用实验动物的代号、性别、电极追踪图像列表与说明及其他相关信息； - DataSet2_ElectrodesGroups.csv：声音范式实验中神经元分析分组的详细说明； - DataSet2_NeuronsList.csv：本数据集记录神经元的列表与详细说明； - DataSet2_UnitsRecordingsStr_BehaviourProtocol.rtf：行为范式实验的行为范式与采集数据说明文档； - DataSet2_UnitsRecordingsStr_SoundProtocol.rtf：声音范式实验的行为范式与采集数据说明文档。 ### 数据集3：BA向DMS与PrL的输入投射在决策行为中的作用 本实验旨在阐明在决策行为范式中，PrL与DMS的神经活动受BA传入纤维调控的机制。 相关文件如下： - DataSet3_GamblingTask_Data.zip：包含本实验的原始与一手数据，数据格式为.mat、.continuous、.events等； - DataSet3_GamplingTask_InjectionElectrodesLocation.zip：包含本实验各动物的电极穿刺追踪图像与注射位点图像，数据格式为.jpg； - DataSet3_AnimalCodes.csv：本数据集所用实验动物的代号、性别及其他相关信息列表； - DataSet3_GamblingTask_NeuronsList.csv：本数据集记录神经元的列表与详细说明； - DataSet3_GamblingTask_Protocol.rtf：本实验的行为范式与采集数据说明文档； - DataSet3_TissueData.csv：注射位点图像的列表与说明文档。 所有视频、TTL信号、记录数据与追踪数据均可按需提供。请联系邮箱pardo-bellver.cecilia(a)koki.hu。