Supplementary Material for: No efficacy with non-invasive brain stimulation 1 for painful legs and moving toes: A Case report

Introduction: Painful legs and moving toes (PLMT) is a rare neurological disorder characterized by neuropathic pain and involuntary movements in the lower limbs. The pathophysiological mechanisms are unclear but central mechanisms might be involved suggesting that non-invasive brain stimulation might be helpful. Thus far no reports have been published on non-invasive brain stimulation to treat PLMT. Case presentation: a 70-year old female had a one year history of PLMT. After several unsuccessful medical attempts the patient received repetitive transcranial magnetic stimulation and transcranial direct current stimulation to alleviate the pain and involuntary movements with no benefit. Conclusion: This is a first report on non-invasive brain stimulation in a PLMT patient. Although ineffective in our patient non-invasive brain stimulation should be further studied in this often difficult to treat and debilitating syndrome.