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THYMIDYLATE SYNTHASE COMPLEX WITH 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP) AND FOLATE ANALOG 1843U89

NIAID Data Ecosystem2026-05-02 收录

胸苷酸合酶复合物结构

叶酸代谢抑制剂

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THYMIDYLATE SYNTHASE COMPLEX WITH 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP) AND FOLATE ANALOG 1843U89

应用场景：

创建时间：

2025-03-26

抗结核药物研发

叶酸代谢抑制剂

This dataset is part of a research project aimed to understand the impact of folate pathway inhibition on developing anti-tuberculosis agents.

NIAID Data Ecosystem70

Structure-Guided Optimization of Small-Molecule Folate Uptake Inhibitors Targeting the Energy-Coupling Factor Transporters

抗菌药物开发

叶酸代谢抑制剂

Here, we report on a potent class of substituted ureidothiophenes targeting energy-coupling factor (ECF) transporters, an unexplored target that is not addressed by any antibiotic in the market. Since

NIAID Data Ecosystem40

Employing a ZTP Riboswitch to Detect Bacterial Folate Biosynthesis Inhibitors in a Small Molecule High-Throughput Screen

抗菌药物筛选

叶酸代谢抑制剂

Various riboswitch classes are being discovered that precisely monitor the status of important biological processes, including metabolic pathway function, signaling for physiological adaptations, and

Figshare2019-10-14 更新30

Mechanisms of Resistance to Folate Pathway Inhibitors in Burkholderia pseudomallei: Deviation from the Norm

抗生素耐药机制

叶酸代谢抑制剂

Burkholderia pseudomallei causes melioidosis, a tropical disease that is difficult to treat. The bacterium’s resistance to antibiotics limits therapeutic options. The paucity of orally available drugs

NIAID Data Ecosystem50

Para-aminosalicylic acid acts as an alternative substrate of folate metabolism in Mycobacterium tuberculosis

结核病药物机制

叶酸代谢抑制剂

Folate biosynthesis is an established anti-infective target, and the antifolate para-aminosalicylic acid (PAS) was one of the first anti-infectives introduced into clinical practice on the basis of ta

DataONE2020-06-24 更新40

THYMIDYLATE SYNTHASE COMPLEX WITH 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP) AND FOLATE ANALOG 1843U89

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